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	febrile seizures

Disease ID	1426
Disease	febrile seizures
Definition	Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
Synonym	[d]convulsions, febrile [d]convulsions, febrile (context-dependent category) [d]convulsions, febrile (situation) [d]pyrexial convulsion convulsion febrile convulsion fever convulsion, febrile convulsion, fever convulsion, pyrexial convulsions febrile seizures convulsions, febrile convulsions, fever convulsions, pyrexial febrile convulsion febrile convulsion (finding) febrile convulsion seizure febrile convulsion seizures febrile convulsions febrile convulsions (finding) febrile convulsions (simple), unspecified febrile convulsions nos febrile fit febrile fits febrile seizure febrile seizure (from fever) febrile seizures nos fever convulsion fever convulsions fever induced seizures fever seizure fever seizures fevers seizures fit, febrile fits, febrile pyrexial convulsion pyrexial convulsions pyrexial seizure pyrexial seizures seizure febrile seizure fever seizure, febrile seizure, febrile convulsion seizure, fever seizure, pyrexial seizures fever seizures, febrile seizures, febrile [disease/finding] seizures, febrile convulsion seizures, febrile, in early childhood seizures, fever seizures, generalized, associated with fever seizures, pyrexial
UMLS	C0009952
MeSH	D003294
SNOMED-CT	SNOMEDCT_US_2016_09_01:41497008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:37) C0014544 \| epilepsy \| 96 C0017160 \| gastroenteritis \| 6 C0014544 \| epilepsies \| 4 C0014556 \| temporal lobe epilepsy \| 4 C0343363 \| rotavirus gastroenteritis \| 3 C0679466 \| cognitive deficits \| 2 C0021400 \| influenza \| 2 C0014547 \| partial epilepsy \| 2 C0002871 \| anemia \| 2 C0751122 \| dravet syndrome \| 1 C0162316 \| iron deficiency anemia \| 1 C0015231 \| exanthem subitum \| 1 C0015230 \| exanthem \| 1 C0020456 \| hyperglycemia \| 1 C0011991 \| diarrhea \| 1 C0042769 \| viral infections \| 1 C0014038 \| encephalitis \| 1 C0162316 \| iron-deficiency anemia \| 1 C0015230 \| rash \| 1 C0024530 \| malaria \| 1 C0037317 \| sleep disturbance \| 1 C0014553 \| absence epilepsy \| 1 C0243010 \| viral encephalitis \| 1 C0085437 \| bacterial meningitis \| 1 C0025007 \| measles \| 1 C0042769 \| virus infection \| 1 C0035021 \| recurrent fever \| 1 C0031069 \| familial mediterranean fever \| 1 C0035309 \| retinopathy \| 1 C0035455 \| rhinitis \| 1 C0013418 \| abnormal labor \| 1 C0014553 \| childhood absence epilepsy \| 1 C0042769 \| viral infection \| 1 C0004096 \| asthma \| 1 C0159020 \| neonatal seizures \| 1 C2607914 \| allergic rhinitis \| 1 C0003467 \| anxiety \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) 6324 \| SCN1B \| CTD_human 6323 \| SCN1A \| CTD_human;GWASCAT 6326 \| SCN2A \| CTD_human;GWASCAT 1460 \| CSNK2B \| GWASCAT 63982 \| ANO3 \| CTD_human 4179 \| CD46 \| GWASCAT 2566 \| GABRG2 \| CTD_human 3613 \| IMPA2 \| CTD_human 112755 \| STX1B \| CTD_human 7918 \| GPANK1 \| GWASCAT 10964 \| IFI44L \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:27) 1137 \| CHRNA4 \| CIPHER 1268 \| CNR1 \| CIPHER 2566 \| GABRG2 \| CIPHER;CTD_human 2697 \| GJA1 \| CIPHER 3553 \| IL1B \| CIPHER 6326 \| SCN2A \| CIPHER;CTD_human 6508 \| SLC4A3 \| CIPHER 6548 \| SLC9A1 \| CIPHER 6550 \| SLC9A3 \| CIPHER 627 \| BDNF \| CIPHER 1141 \| CHRNB2 \| CIPHER 1455 \| CSNK1G2 \| CIPHER 610 \| HCN2 \| CIPHER 3586 \| IL10 \| CIPHER 3552 \| IL1A \| CIPHER 3554 \| IL1R1 \| CIPHER 3557 \| IL1RN \| CIPHER 3565 \| IL4 \| CIPHER 3569 \| IL6 \| CIPHER 3613 \| IMPA2 \| CIPHER;CTD_human 4852 \| NPY \| CIPHER 57526 \| PCDH19 \| CIPHER 7124 \| TNF \| CIPHER 63982 \| ANO3 \| CTD_human 112755 \| STX1B \| CTD_human 6323 \| SCN1A \| CTD_human 6324 \| SCN1B \| CTD_human
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1426
Disease	febrile seizures
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:38) HP:0001250 \| Seizures \| 12 HP:0001945 \| Fever \| 7 HP:0001891 \| Iron-deficiency anemia \| 3 HP:0011947 \| Respiratory infection \| 3 HP:0001903 \| Anemia \| 3 HP:0001249 \| Mental retardation \| 2 HP:0100543 \| Cognitive deficits \| 2 HP:0003401 \| Paresthesia \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0001268 \| Mental deterioration \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0002099 \| Asthma \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0002315 \| Headaches \| 1 HP:0000573 \| Retinal hemorrhage \| 1 HP:0001948 \| Alkalosis \| 1 HP:0007018 \| Attention deficits \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0000713 \| Agitation \| 1 HP:0001950 \| Respiratory alkalosis \| 1 HP:0003193 \| Allergic rhinitis \| 1 HP:0012384 \| Nasal inflammation \| 1 HP:0002014 \| Diarrhea \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0000988 \| Exanthem \| 1 HP:0002883 \| Rapid breathing \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0006846 \| Acute encephalopathy \| 1 HP:0001317 \| Abnormality of the cerebellum \| 1 HP:0002788 \| Recurrent upper respiratory infection \| 1 HP:0000739 \| Anxiety \| 1 HP:0002197 \| Generalized seizures \| 1 HP:0003074 \| High blood glucose \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0002383 \| Encephalitis \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0011171 \| Simple fever fit \| 1 HP:0002360 \| Sleep disturbance \| 1

Disease ID	1426
Disease	febrile seizures
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C0424755 \| fever C0042769 \| viral infections C0014556 \| temporal lobe epilepsy C0014548 \| generalized epilepsies C0014544 \| epilepsy C0014544 \| epilepsies
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0014544 \| epilepsy \| 91 C0014556 \| temporal lobe epilepsy \| 4 C0015967 \| fever \| 4 C0014544 \| epilepsies \| 2 C0042769 \| viral infections \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:41)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11105468	25344690	6323	SCN1A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	LOC105369890	12	89935056	T	A
rs11105468	25344690	6326	SCN2A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.246362715	2014	LOC105369890	12	89935056	T	A
rs11105468	25344690	63982	ANO3	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.120271442	2014	LOC105369890	12	89935056	T	A
rs114444506	25344690	6326	SCN2A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.246362715	2014	ANO3	11	26325284	T	C
rs114444506	25344690	6323	SCN1A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	ANO3	11	26325284	T	C
rs114444506	25344690	63982	ANO3	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.120271442	2014	ANO3	11	26325284	T	C
rs121909673	21930603	2566	GABRG2	umls:C0009952	BeFree	The R46W mutation is located in a region homologous to a GABA(A) receptor γ2 subunit missense mutation, R82Q, that is associated with CAE and febrile seizures in humans.	0.142613009	2011	GABRG2	5	162093965	G	A
rs121917748	17641256	6326	SCN2A	umls:C0009952	BeFree	We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures.	0.246362715	2007	SCN2A	2	165308751	C	T
rs121917748	17641256	2566	GABRG2	umls:C0009952	BeFree	We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures.	0.142613009	2007	SCN2A	2	165308751	C	T
rs121917748	11371648	6326	SCN2A	umls:C0009952	BeFree	Here, we report a mutation resulting in an amino acid exchange (R188W) [corrected] in the gene encoding the alpha-subunit of neuronal voltage-gated Na(+) channel type II (Na(v)1.2) in a patient with FS associated with afebrile seizures.	0.246362715	2001	SCN2A	2	165308751	C	T
rs13004083	25344690	101929680	LOC101929680	umls:C0009952	GWASCAT	Common variants associated with general and MMR vaccine-related febrile seizures.	0.12	2014	SCN1A;LOC101929680	2	166088857	A	G
rs13004083	25344690	6323	SCN1A	umls:C0009952	GWASCAT	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	SCN1A;LOC101929680	2	166088857	A	G
rs1318653	25344690	4179	CD46	umls:C0009952	BeFree	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	C1orf132	1	207841577	T	C
rs1318653	25344690	10964	IFI44L	umls:C0009952	BeFree	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	C1orf132	1	207841577	T	C
rs16850331	20041941	6326	SCN2A	umls:C0009952	BeFree	Two SCN2A SNPs (rs3943809 and rs16850331) were associated by case-control with a subgroup with IGE and history of febrile seizures and also by transmission disequilibrium test (TDT) in parent-proband trios.	0.246362715	2010	SCN2A	2	165292743	C	T
rs1799724	19055487	3569	IL6	umls:C0009952	BeFree	The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TNFA -1037C/T) were examined in 249 patients with FS (186 simple and 63 complex FS) and 225 controls.	0.008815624	2009	LTA;TNF	6	31574705	C	T
rs1799724	19055487	7124	TNF	umls:C0009952	BeFree	The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TNFA -1037C/T) were examined in 249 patients with FS (186 simple and 63 complex FS) and 225 controls.	0.00554839	2009	LTA;TNF	6	31574705	C	T
rs211014	17641256	2566	GABRG2	umls:C0009952	BeFree	We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures.	0.142613009	2007	GABRG2	5	162149412	C	A
rs211014	17641256	6326	SCN2A	umls:C0009952	BeFree	We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures.	0.246362715	2007	GABRG2	5	162149412	C	A
rs211037	23140995	2566	GABRG2	umls:C0009952	BeFree	This study showed significant association of GABRG2 rs211037 with susceptibility to FS, caused by two studies with small sample sizes, however the possibility of false positive results due to the effect of significant studies for FS cannot be excluded.	0.142613009	2013	GABRG2	5	162101274	C	T
rs211037	24061200	2566	GABRG2	umls:C0009952	BeFree	GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures.	0.142613009	2014	GABRG2	5	162101274	C	T
rs2724384	25344690	4179	CD46	umls:C0009952	GWASCAT	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	CD46	1	207756858	G	A
rs273259	25344690	10964	IFI44L	umls:C0009952	BeFree	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	IFI44L	1	78628133	A	G
rs273259	25344690	4179	CD46	umls:C0009952	BeFree	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	IFI44L	1	78628133	A	G
rs273259	25344690	10964	IFI44L	umls:C0009952	GWASCAT	Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).	0.120271442	2014	IFI44L	1	78628133	A	G
rs2910164	25319229	3146	HMGB1	umls:C0009952	BeFree	Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children.	0.000271442	2014	LOC285628;MIR146A	5	160485411	C	G
rs2910164	25319229	406938	MIR146A	umls:C0009952	BeFree	Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children.	0.000271442	2014	LOC285628;MIR146A	5	160485411	C	G
rs3130618	25344690	7918	GPANK1	umls:C0009952	GWASCAT	Common variants associated with general and MMR vaccine-related febrile seizures.	0.12	2014	CSNK2B;GPANK1	6	31664357	C	A
rs3130618	25344690	1460	CSNK2B	umls:C0009952	GWASCAT	Common variants associated with general and MMR vaccine-related febrile seizures.	0.12	2014	CSNK2B;GPANK1	6	31664357	C	A
rs3769955	25344690	6326	SCN2A	umls:C0009952	GWASCAT	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.246362715	2014	SCN2A	2	165378122	C	T
rs3769955	25344690	63982	ANO3	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.120271442	2014	SCN2A	2	165378122	C	T
rs3769955	25344690	6323	SCN1A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	SCN2A	2	165378122	C	T
rs3769955	25344690	6326	SCN2A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.246362715	2014	SCN2A	2	165378122	C	T
rs3812718	22578703	6323	SCN1A	umls:C0009952	BeFree	Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis.	0.277300664	2012	SCN1A	2	166053034	C	T
rs3812718	24076350	6323	SCN1A	umls:C0009952	BeFree	SCN1A rs3812718 polymorphism and susceptibility to epilepsy with febrile seizures: a meta-analysis.	0.277300664	2013	SCN1A	2	166053034	C	T
rs386602118	15279867	627	BDNF	umls:C0009952	BeFree	Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures.	0.002995792	2004	NA	NA	NA	NA	NA
rs3943809	20041941	6326	SCN2A	umls:C0009952	BeFree	Two SCN2A SNPs (rs3943809 and rs16850331) were associated by case-control with a subgroup with IGE and history of febrile seizures and also by transmission disequilibrium test (TDT) in parent-proband trios.	0.246362715	2010	SCN2A	2	165344371	A	G
rs6432860	25344690	6323	SCN1A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	SCN1A	2	166041354	A	G,T
rs6432860	25344690	6323	SCN1A	umls:C0009952	GWASCAT	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.277300664	2014	SCN1A	2	166041354	A	G,T
rs6432860	25344690	63982	ANO3	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.120271442	2014	SCN1A	2	166041354	A	G,T
rs6432860	25344690	6326	SCN2A	umls:C0009952	BeFree	Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)).	0.246362715	2014	SCN1A	2	166041354	A	G,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1426
Disease	febrile seizures
Case	(Waiting for update.)